The BSE Sensex slumped over 726 points, slipping below the 51,000-level in opening trade due to a meltdown in global shares and the surge in bond yields.
Sensex was trading at 50,718.36, showing a fall of 726.29 points or 1.41 per cent.
NSE Nifty was trading down 197.05 points or 1.29 per cent at 15,048.55.
On the Sensex chart, HDFC duo fell as much as 2.48 per cent, followed by Bajaj FinServ, Kotak Bank, and Bajaj Finance – dropping up to 2.23 per cent.
Of Sensex shares, 27 traded in the red.
Over the previous three sessions, the Sensex had risen by 2,344.66 points or 4.77 per cent, while the Nifty had added 716.45 points or 4.93 per cent.
Asian shares tumbled on Thursday after an overnight surge in bond yields that dragged Wall Street lower.
"Bond yields are now exerting a major influence on stock prices, globally. After spiking to 1.6 per cent on February 25, the US 10-year yield fell to 1.4 per cent and yesterday it has again risen to 1.48 per cent impacting equity markets," said V K Vijayakumar, Chief Investment Strategist at Geojit Financial Services.
Foreign investors had bought equities worth Rs 2,088.70 crore on a net basis in Indian capital markets on Wednesday, according to exchange data.
Meanwhile, global crude oil benchmark Brent was trading 0.36 per cent higher at $64.22 per barrel.