Equity benchmark indices settled on a weaker note on Friday amid selling across the sectors due to weak global cues and profit booking at higher levels. The BSE Sensex fell 793.25 points or 1.06 percent to close at 74,244.90. The NSE Nifty50 was down 234.40 points or 1.03 percent to settle at 22,519.40. BSE Midcap and Smallcap indices fell 0.5 per cent each. All sectors including midcap and smallcap ended in red with Oil & Gas, PSU Bank, and Pharma being major losers.